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In vitro and in vivo effects of N-methyl-3,5-dichlorobenzylamine hydrochloride on Mycobacterium leprae

Dhople, A. M. ; Strong, L. C. ; Meindl, W. ; Schönenberger, Helmut ; Gardner, G. D.



Abstract

The antimicrobial effects of a new benzylamine, ME-93 (I), alone and in combination with dapsone and rifampicin, have been evaluated in vitro in cell-free culture system and in vivo in mouse foot pad system. Even at 50 micro g/mL, ME-93 did not completely inhibit the in vitro growth of M. leprae, and the effects were bacteriostatic. However, there was a synergism when ME-93 was combined with ...

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