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Abstract
The impulse conduction velocity of frog heart ventricle strips was reduced 50% by 9.5 * 10-6M N-[2-(diethylamino)ethyl]-2-methoxycinchoninamide, 1.95 * 10-6M N-[2-(diethylamino)-ethyl]-2-ethoxycinchoninamide, 0.9 * 10-6M N-[2-(diethylamino)ethyl]-2-propoxycinchoninamide, 0.5 (I), 1.1 * 10-6M N-[2-(diethylamino)ethyl]-2-(pentyloxy)cinchoninamide, and 23.5 * 10-6M ...
Abstract
The impulse conduction velocity of frog heart ventricle strips was reduced 50% by 9.5 * 10-6M N-[2-(diethylamino)ethyl]-2-methoxycinchoninamide, 1.95 * 10-6M N-[2-(diethylamino)-ethyl]-2-ethoxycinchoninamide, 0.9 * 10-6M N-[2-(diethylamino)ethyl]-2-propoxycinchoninamide, 0.5 (I), 1.1 * 10-6M N-[2-(diethylamino)ethyl]-2-(pentyloxy)cinchoninamide, and 23.5 * 10-6M N-[2-(diethylamino)ethyl]-2-(hexyloxy)cinchoninamide. These results agree with previous results of surface anesthetic activity, I being the most effective. The inhibitory effect of the I homologs decreased as the pH was increased from 6.4 to 8.2, indicating that the cationic form is more effective than the free base.
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