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Mode of local anesthetic activity of cinchocaine homologs

Petter, Alfred ; Schönenberger, Helmut ; Zwez, W.



Abstract

The impulse conduction velocity of frog heart ventricle strips was reduced 50% by 9.5 * 10-6M N-[2-(diethylamino)ethyl]-2-methoxycinchoninamide, 1.95 * 10-6M N-[2-(diethylamino)-ethyl]-2-ethoxycinchoninamide, 0.9 * 10-6M N-[2-(diethylamino)ethyl]-2-propoxycinchoninamide, 0.5 (I), 1.1 * 10-6M N-[2-(diethylamino)ethyl]-2-(pentyloxy)cinchoninamide, and 23.5 * 10-6M ...

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