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Mechanism of action of local anesthetics. 5. Influence of stereoisomers of N-(N-dimethylphenylalanyl) ephedrine on the steady state current-voltage behavior of Ranviers' node

Petter, A. ; Schönenberger, Helmut ; Zwez, W.



Abstract

Measurements of action potentials and stationary voltage-current characteristics on Ranvier nodes of the isolated nervus ischiadicus of Rana esculenta showed that N-(L-N,N-dimethylphenylalanyl)-D-ephedrine [2480-20-8] and N-(D-N,N-dimethylphenylalanyl)-L-ephedrine [7278-68-4] decreased the Na [7440-23-5] cond. of the nodes. The 2 enantiomers of the local anesthetic had approx. the same activity.


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