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Mechanism of action of local anesthetics. 2. Demonstration of the differential effect of enantiomeric local anesthetics

Petter, A. ; Schönenberger, Helmut ; Zwez, W.


The 8 stereoisomers of N-[N-dimethylphenylalanyl]ephedrine [10385-91-8], the 2 stereoisomers of N-[N-dimethylalanyl]-2,6-dimethylaniline [19216-39-8] (I, R = H), and the 2 stereoisomers of N-[N-dimethylphenylalanyl]-2,6-dimethylaniline [19216-40-1] (I, R = Ph) were synthesized and tested, as models of local anesthetics, for their ability to slow the impulse conduction velocity of frog ventricle ...


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