Ruckdeschel, G., Stransky, D. and Schönenberger, Helmut (1976) Studies of the correlation between structure and tuberculostatic effect of the benzylamine class. Pharmazie 31 (6), pp. 374-381.
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Abstract
Among 114 N-alkylbenzylamines and their derivs. tested, N-butyl-3-fluorobenzylamine (I) [60509-34-4] showed the highest tuberculostatic activity (min. inhibitory concn. 30 micro g/ml against Mycobacterium tuberculosis in vitro. Several other N-alkylbenzylamines with or without ring substituents showd good activity, whereas compds. substituted in the CH2 group of the benzyl residue, or coupled to ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 1976 | ||||
| Additional Information (public): | CAN 85:137174 1-3 Pharmacodynamics 2090-62-2P; 33597-22-7P; 60508-96-5P; 60509-14-0P; 60509-15-1P; 60509-16-2P; 60509-17-3P; 60509-18-4P; 60509-19-5P; 60509-21-9P; 60509-22-0P; 60509-23-1P; 60509-24-2P; 60509-25-3P; 60509-26-4P; 60509-27-5P; 60509-28-6P; 60509-29-7P; 60509-30-0P; 60509-31-1P; 60509-32-2P; 60509-44-6P; 60509-45-7P; 60509-51-5P; 60509-52-6P; 60509-53-7P; 60509-55-9P; 60509-56-0P; 60509-57-1P; 60509-58-2P; 60509-59-3P; 60509-60-6P; 60509-61-7P; 60509-73-1P; 60509-74-2P; 60537-66-8P; 60580-47-4P; 61013-31-8P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and tuberculostatic activity of); 60509-75-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 99-61-6; 123-08-0; 500-22-1; 529-23-7; 552-89-6; 555-16-8; 556-18-3; 619-66-9; 1709-44-0 Role: BIOL (Biological study) (reaction with alkylamines and redn. of); 90-02-8; 100-52-7; 100-83-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction with alkylamines and redn. of); 75-64-9; 78-81-9; 96-20-8; 107-10-8; 109-73-9; 124-22-1; 13952-84-6 Role: BIOL (Biological study) (reaction with benzaldehyde and Grignard reagents); 6852-58-0 Role: BIOL (Biological study) (reaction with cyanide); 100-46-9; 102-97-6; 103-67-3; 1165-52-2; 1667-16-9; 2032-33-9; 2049-94-7; 2403-22-7; 2403-38-5; 3378-72-1; 5730-02-9; 14321-27-8; 16183-21-4; 16183-28-1; 16183-35-0; 16183-39-4; 22704-59-2; 25468-43-3; 25468-44-4; 42882-36-0; 46120-25-6; 60508-94-3; 60508-95-4; 60508-97-6; 60508-98-7; 60508-99-8; 60509-00-4; 60509-01-5; 60509-02-6; 60509-03-7; 60509-04-8; 60509-05-9; 60509-06-0; 60509-07-1; 60509-08-2; 60509-09-3; 60509-10-6; 60509-11-7; 60509-12-8; 60509-13-9; 60509-33-3; 60509-34-4; 60509-35-5; 60509-36-6; 60509-37-7; 60509-38-8; 60509-39-9; 60509-40-2; 60509-41-3; 60509-42-4; 60509-43-5; 60509-46-8; 60509-47-9; 60509-48-0; 60509-49-1; 60509-50-4; 60509-54-8; 60509-62-8; 60509-63-9; 60509-64-0; 60509-65-1; 60509-66-2; 60509-67-3; 60509-68-4; 60509-69-5; 60509-70-8; 60509-71-9; 60509-72-0; 60509-76-4; 60509-77-5 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (tuberculostatic activity of) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger | ||||
| Identification Number: |
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| Keywords: | Tuberculostatics (alkylbenzylamine) Molecular structure-biological activity relationship (tuberculostatic, of alkylbenzylamines) alkylbenzylamine tuberculostatic Mycobacterium alkylbenzylamine benzylamine alkyl tuberculostatic | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Unknown | ||||
| Item ID: | 18128 |
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