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Studies of the correlation between structure and tuberculostatic effect of the benzylamine class

Ruckdeschel, G. ; Stransky, D. ; Schönenberger, Helmut



Abstract

Among 114 N-alkylbenzylamines and their derivs. tested, N-butyl-3-fluorobenzylamine (I) [60509-34-4] showed the highest tuberculostatic activity (min. inhibitory concn. 30 micro g/ml against Mycobacterium tuberculosis in vitro. Several other N-alkylbenzylamines with or without ring substituents showd good activity, whereas compds. substituted in the CH2 group of the benzyl residue, or coupled to ...

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