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Antimycobacterial properties of N-alkylbenzylamines

Ruckdeschel, G. ; Stransky, D. ; Schönenberger, Helmut


A no. of N-alkylbenzylamines were tested for antimycobacterial activity against various strains of Mycobacterium, as were many commonly used tuberculostatics. N-butyl-3-fluorobenzylamine (I) [60509-34-4] was the most active of the alkylbenzylamines, but pronounced inhibitory activity was also shown by N-butylbenzylamines with 3-chloro, 3-iodo, 3-nitro, or 4-dimethylamino substituents.

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