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Chemistry and mode of action of aminomethylating carcinostatics. II. Cytostatics

Schönenberger, Helmut ; Adam, Adelheid



Abstract

cf. CA 63, 5474c. The growth of Ehrlich ascites tumor in mice was inhibited by mono- and dialkylthiomethylamine derivs., which react with the higher H+ concn. in tumor cells to give carbonium-immoninm ions which alkylate the substrate. The low toxicity of these compds. is explained by the ease with which the alpha -aminoalkyl radical splits from the blocked substrate. Melamine and formalin at pH ...

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