Alternative links to fulltext:
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Arzneimittel-Forschung = Drug research | ||||
| Publisher: | Editio-Cantor-Verlag | ||||
| Volume: | 16 | ||||
| Number of Issue or Book Chapter: | 6 | ||||
| Page Range: | pp. 734-738 | ||||
| Date: | 1966 | ||||
| Additional Information (public): | CAN 65:50925 68 Pharmacodynamics 872-44-6 (Pyrrolidinium, 1,1-dimethyl-, iodide); 1017-56-7 (Methanol, (s-triazine-2,4,6-triyltriimino)tri-); 1952-37-0 (Ethanol, 2-[(p-hydroxybenzylidene)amino]-); 2037-00-5 (Methanol, (diethylamino)-, acetate (ester); 3089-11-0 (Melamine, hexakis(methoxymethyl)-); 3275-13-6 (Piperidine, 1-(ethoxymethyl)-); 5752-37-4 (Melamine, hexakis[(ethylthio)methyl]-); 5752-43-2 (Ethylenediamine, N,N,N',N'-tetrakis[(ethylthio)methyl]-); 5766-67-6 (Acetonitrile, (ethylenedinitrilo)tetra-); 5766-68-7 (Glycinonitrile, N,N'-ethylenebis[N-methyl-); 5766-69-8 (Glycinonitrile, N,N'-(6-chloro-s-triazine-2,4-diyl)di-); 5766-70-1 (Glycinonitrile, N,N'-(6-amino-s-triazine-2,4-diyl)di-); 5766-74-5 (Phenol, p-(N-methylformimidoyl)-); 5766-75-6 (Pyrocatechol, 4-(N-methylformimidoyl)-); 5766-76-7 (Anthranilic acid, N-benzylidene-); 5766-79-0 (1-Piperidineacetonitrile, alpha -phenyl-); 13046-06-5 (Methanesulfonic acid, (s-triazine-2,4,6-triyltriimino)tri-, trisodium salt); 13046-10-1 (Methanesulfonic acid, (ethylenedinitrilo)tetra-, tetrasodium salt); 14451-14-0 (Methanesulfonic acid, [(ethylenebis(methylimino)di-, disodium salt) (neoplasm inhibition and); 51-46-7 (1,3,6,8-Tetraazatricyclo[4.4.1.13,8]dodecane); 51-80-9 (Methanediamine, N,N,N',N'-tetramethyl-); 51-82-1 (Carbamic acid, dimethyldithio-, (dimethylamino)methyl ester); 51-82-1 (Methanethiol, (dimethylamino)-, dimethyldithiocarbamate); 4082-71-7 (Imidazolidine, 1,3-bis[(ethylthio)methyl]-, dihydrochloride); 4135-86-8 (Ethylenediamine, N,N'-bis[(ethylthio)methyl]-N,N'-dimethyl-, dihydrochloride) (neoplasm inhibition by) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger | ||||
| Identification Number: |
| ||||
| Keywords: | Neoplasms (inhibitors of, aminomethylating compds. as) | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Unknown | ||||
| Item ID: | 18136 |
Abstract
The carcinostatic effects of 24 aminomethylating compds. were tested against Ehrlich ascites carcinoma and sarcoma 180 in mice and against Yoshida sarcoma in rats. Intraperitoneal injections of N,N'-dimethyl-N,N'-diethylthiomethylethylenediamine dihydrochloride (3400 mg./kg.), N,N'-diethylthiomethylimidazolidine dihydrochloride (2500 mg./kg.), 1,4,6,9-tetraazatricyclo[4.4.1.1.9,4]dodecane (575 ...
Abstract
The carcinostatic effects of 24 aminomethylating compds. were tested against Ehrlich ascites carcinoma and sarcoma 180 in mice and against Yoshida sarcoma in rats. Intraperitoneal injections of N,N'-dimethyl-N,N'-diethylthiomethylethylenediamine dihydrochloride (3400 mg./kg.), N,N'-diethylthiomethylimidazolidine dihydrochloride (2500 mg./kg.), 1,4,6,9-tetraazatricyclo[4.4.1.1.9,4]dodecane (575 mg./kg.), dimethylaminomethyl N,N-dimethyldithiocarbamate (1050 mg./kg.), and N,N,N'N'-tetramethyldiaminomethane (1046 mg./kg.) caused healing in at least 50% of the mice bearing Ehrlich ascites carcinoma but were only slightly effective against Yoshida sarcoma and were completely inactive against sarcoma 180.
Metadata last modified: 24 May 2018 12:19
Owner only: item control page
Altmetric