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The action of aminomethylating carcinostatics on experimental tumors. IV. Cytostatic agents

Schönenberger, Helmut ; Adam, A. ; Adam, D.



Abstract

The carcinostatic effects of 24 aminomethylating compds. were tested against Ehrlich ascites carcinoma and sarcoma 180 in mice and against Yoshida sarcoma in rats. Intraperitoneal injections of N,N'-dimethyl-N,N'-diethylthiomethylethylenediamine dihydrochloride (3400 mg./kg.), N,N'-diethylthiomethylimidazolidine dihydrochloride (2500 mg./kg.), 1,4,6,9-tetraazatricyclo[4.4.1.1.9,4]dodecane (575 ...

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