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Cytostatics. 15. Antimicrobial and antitumor properties of nitrogen-containing stilbestrol analogs

Schönenberger, Helmut ; Bastug, T.



Abstract

Me2NCH2C(C6H4R-p):C(C6H4R-p)Et [I, R = H (II) or OMe (III)] were prepd. by reaction of Me2NCH2CH(C6H4R-p)COC6H4R-p with EtMgBr and dehydration of the resulting alc. with PCl3. Ether cleavage of III with AlBr3 in C6H6 gave I [R = OH (IV)]. II and IV had no estrogenic properties. II, III, and IV showed no antibacterial effects in vitro and only low activity against mouse sarcoma 180 and rat Yoshida ...

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