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Cytostatics. 13. Synthesis of meso-N,N'-dimethyl-alpha ,alpha '-bis(4-hydroxyphenyl)ethylenediamine

Schönenberger, Helmut and Bernhauer, H. (1970) Cytostatics. 13. Synthesis of meso-N,N'-dimethyl-alpha ,alpha '-bis(4-hydroxyphenyl)ethylenediamine. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 303 (10), pp. 804-812.

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Treatment of p-MeC6H4CHO with 33% MeNH2 gave 88% p-MeOC6H4CH:NMe (I). Redn. of I in PhMe with activated Al (prepd. from EtOH, Al foil, and HgCl2 heated at 80 Deg) and treatment with HCl-Et2O gave 22.8% p-MeOC6H4CH2NHMe.HCl (II), 38.3% meso-p-MeOC6-H4CH(NHMe)CH(NHMe)C6H4OMe-p (meso-III).2HCl, 16.7% (+-)-III.2HCl, 4.6% (+-)-IV. HCl, and 3.3% meso-IV. Refluxing meso-III.2HCl or (+-)-III.2HCl with ...


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Item type:Article
Additional Information (public):CAN 74:3376 25 Noncondensed Aromatic Compounds 702-24-9P; 876-32-4P; 13114-23-3P; 30033-66-0P; 30033-67-1P; 30033-68-2P; 30197-24-1P; 30197-25-2P; 30197-26-3P; 30197-27-4P; 30197-28-5P; 30246-41-4P; 30246-42-5P; 30246-43-6P; 30296-37-8P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
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Keywords:hydroxyphenyl ethylenediamines ethylenediamines hydroxyphenyl amines ethylene phenols anisoles phenols anisoles amines ethylene anisoles phenols amines ethylene imidazolidines phenyl
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:18145
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