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Synthesis and local anesthetic action of N-(piperidinomethyl)-4-alkoxybenzamides

Schönenberger, Helmut, Bindl, L., Petter, A. and Zwez, W. (1970) Synthesis and local anesthetic action of N-(piperidinomethyl)-4-alkoxybenzamides. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 303 (10), pp. 798-804.

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Heating 4-BuOC6H4CONH2, HCHO, and piperidine gave 67% I (R = BuO) (II). Similarly prepd. were 4 other I (R = C1-5 alkoxy) and I (R = H). I inhibits impulse conduction in frog ventricle strips. II had a 50% inhibitory concn. of 3.4 micro M at pH 7.6.

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Item type:Article
Additional Information (public):CAN 74:22660 27 Heterocyclic Compounds (One Hetero Atom) 4380-83-0P; 13315-02-1P; 27876-79-5P; 27876-81-9P; 27876-82-0P; 28835-09-8P; 30083-77-3P; 30083-79-5P; 30083-81-9P; 30083-83-1P; 30083-85-3P; 30083-87-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
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Keywords:Anesthetics (piperidinomethylbenzamide derivs. as local) piperidinomethylbenzamides local anesthetics local anesthetics anesthetics local benzamides local anesthetics
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:18147
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