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Synthesis and local anesthetic action of N-(piperidinomethyl)-4-alkoxybenzamides

Schönenberger, Helmut ; Bindl, L. ; Petter, A. ; Zwez, W.


Heating 4-BuOC6H4CONH2, HCHO, and piperidine gave 67% I (R = BuO) (II). Similarly prepd. were 4 other I (R = C1-5 alkoxy) and I (R = H). I inhibits impulse conduction in frog ventricle strips. II had a 50% inhibitory concn. of 3.4 micro M at pH 7.6.

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