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Resolution of N-(DL-N,N-dimethylalanyl)-L-y-ephedrine into its stereoisomeric forms of Craig partition. The possibility of resolution of racemic amino acids into optical isomers using countercurrent methods

Schönenberger, Helmut ; Brinkman, R. ; Bamann, E.



Abstract

DL-N,N-Dimethylalanine (I) was converted into N-(DL-N,N-dimethylalanyl)-L-y-ephedrine (II). II was resolved into its diastereoisomers by a Craig countercurrent partition process using 45:5:50 0.1M citrate buffer (pH 5.98)-MeOHCHCl3. N-(L-N,N-Dimethylalanyl)-L-y-ephedrine (III) m. 97-9 Deg, [alpha ]20D 70 Deg (c 0.007, 5N HCl), and N-(D-N,N-dimethylalanyl)-L-y-ephedrine m. 83-5 Deg, [alpha ]20D ...

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