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Synthesis and testing the cardiocirculatory effects of N-(3'-methoxybenzamidomethyl)-D-norephedrine and analogous compounds

Schönenberger, Helmut ; Petter, Alfred ; Kuehling, Volker ; Bindl, Ludwig


Twenty-six substituted N-benzamidomethyl and 3 N-(diphenylacetamido)methyl amines were prepd. by coupling I groups (R1 = H or MeO; R2 = H, Me MeO, EtO, PrO, or Cl; R3 = H, MeO, or Cl) and Ph2CHCONHCH2 groups, resp., to the N atom of phenylethylamine, amphetamine, phenylethanolamine, norephedrine, ephedrine, norfenefrine, and noradrenaline. Tests on the isolated guinea pig heart showed that the ...


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