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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Archiv der Pharmazie | ||||
| Verlag: | Wiley | ||||
| Band: | 309 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 4 | ||||
| Seitenbereich: | S. 289-301 | ||||
| Datum: | 1976 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 85:40643 1-3 Pharmacodynamics 15687-41-9 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (cardiovascular activity of, norephedrine analogs in relation to); 59630-56-7P; 59630-57-8P; 59630-58-9P; 59630-59-0P; 59630-60-3P; 59630-61-4P; 59630-62-5P; 59630-63-6P; 59630-64-7P; 59630-65-8P; 59630-66-9P; 59630-67-0P; 59630-68-1P; 59630-69-2P; 59630-70-5P; 59630-71-6P; 59630-72-7P; 59630-73-8P; 59630-74-9P; 59630-75-0P; 59630-76-1P; 59630-77-2P; 59630-78-3P; 59630-79-4P; 59630-80-7P; 59630-81-8P; 59630-82-9P; 59643-15-1P; 59643-16-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and cardiovascular activity of); 6282-02-6P; 13855-74-8P; 40478-07-7P; 57428-72-5P; 59630-85-2P; 59630-86-3P; 59630-87-4P; 59630-88-5P; 59630-89-6P; 59630-90-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and chlorination of); 59630-83-0P; 59630-84-1P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Circulation Heart ((methoxybenzamidomethyl)norephedrine and related compds. effect on) cardiovascular catechol amine deriv heart catechol amine deriv circulation catechol amine deriv blood pressure catechol amine deriv norephedrine analog heart circulation | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Unbekannt / Keine Angabe | ||||
| Dokumenten-ID: | 18172 |
Zusammenfassung
Twenty-six substituted N-benzamidomethyl and 3 N-(diphenylacetamido)methyl amines were prepd. by coupling I groups (R1 = H or MeO; R2 = H, Me MeO, EtO, PrO, or Cl; R3 = H, MeO, or Cl) and Ph2CHCONHCH2 groups, resp., to the N atom of phenylethylamine, amphetamine, phenylethanolamine, norephedrine, ephedrine, norfenefrine, and noradrenaline. Tests on the isolated guinea pig heart showed that the ...
Zusammenfassung
Twenty-six substituted N-benzamidomethyl and 3 N-(diphenylacetamido)methyl amines were prepd. by coupling I groups (R1 = H or MeO; R2 = H, Me MeO, EtO, PrO, or Cl; R3 = H, MeO, or Cl) and Ph2CHCONHCH2 groups, resp., to the N atom of phenylethylamine, amphetamine, phenylethanolamine, norephedrine, ephedrine, norfenefrine, and noradrenaline. Tests on the isolated guinea pig heart showed that the desired sepn. of coronary-dilating and pos. inotropic properties was not achieved by any of the compds. Six compds., including N-(3'-methoxybenzamidomethyl)-D-norephedrine-HCl [59630-62-5], had combined pos. inotropic and coronary circulation-promoting effects; none was as active as the ref. compd., oxyfedrine [15687-41-9]. Five N-benzamidomethyl-beta -phenylalkanolamines, synthesized in the hope of obtaining long-acting pressor effects in vivo, showed no activity in this regard. The compds. were synthesized by reaction of Ph2CHCONHCH2Cl or the N-chloromethyl analogs of I with the catechol amines in the presence of Et3N as H+ acceptor.
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