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Correlations between active substance and receptor in local anesthetics of the N-aminoacyl ephedrine type

Schönenberger, Helmut ; Petter, Alfred ; Zwez, W.


The influence of mol. configuration and of pH on the activity of a local anesthetic was detd. by comparing the activities of the 8 stereoisomers of N-(N,N-dimethylphenylalanyl)ephedrine against the isolated ischiadic nerve of frogs and by detg. the median effective dose (ED50) of each stereoisomer required to slow heart ventricle flow rate in frogs by 50% (after 30 min.). The results were as ...


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