Correlations between active substance and receptor in local anesthetics of the N-aminoacyl ephedrine type

Schönenberger, Helmut, Petter, Alfred und Zwez, W. (1967) Correlations between active substance and receptor in local anesthetics of the N-aminoacyl ephedrine type. Pharmaceutica acta Helvetiae 42 (8-10), S. 593-603.

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Zusammenfassung

The influence of mol. configuration and of pH on the activity of a local anesthetic was detd. by comparing the activities of the 8 stereoisomers of N-(N,N-dimethylphenylalanyl)ephedrine against the isolated ischiadic nerve of frogs and by detg. the median effective dose (ED50) of each stereoisomer required to slow heart ventricle flow rate in frogs by 50% (after 30 min.). The results were as ...

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