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Enantiomeric local anesthetics of the N-aminoacyl-2,6-dimethylaniline type

Schönenberger, Helmut, Petter, Alfred and Zwez, W. (1968) Enantiomeric local anesthetics of the N-aminoacyl-2,6-dimethylaniline type. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 301 (10), pp. 780-785.

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Enantiomeric N-aminoacyl-2,6-dimethylanilines were synthesized by condensation of optically active N,N-dimethylalanines or phenylalanines with EtO2- CCl, yielding mixed anhydrides. Reaction of these with 2,6-Me2C6H3NH2 gave optically active N-aminoacyl-2,6-dimethylanilines. Compds. synthesized were [m.p. HCl salt and [alpha ]20D (c, 0.5, H2O) given]: N-(D-N, N-dimethylalanyl)-2,6-dimethylaniline, ...


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Item type:Article
Additional Information (public):CAN 70:38061 34 Synthesis of Amino Acids, Peptides, and Proteins 17655-31-1 (Amide) Role: BAC (Biological activity or effector, except adverse), BIOL (Biological study) (aminoacyl 2,6-xylidides, as anesthetics); 19216-71-8; 19216-72-9; 19216-73-0; 19237-86-6 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (anesthetic activity of); 21400-92-0P; 21400-93-1P; 21400-94-2P; 21400-95-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
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Keywords:Anesthetics (aminoacyl 2,6-xylidides) aminoacyl aniline anesthetic aniline aminoacyl anesthetic anesthetic aminoacyl aniline
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:18176
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