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Mechanism of action of local anesthetics. 6. Binding of local anesthetics to complementary membrane structures

Schönenberger, Helmut, Petter, A. and Zwez, W. (1972) Mechanism of action of local anesthetics. 6. Binding of local anesthetics to complementary membrane structures. Pharmazie 27 (12), pp. 760-767.

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The function of various mol. groups in anesthetic agents such as N-(N-dimethylalanyl)-2,6-dimethylaniline (I) [19216-39-8], N-(N-dimethylphenylalanyl)-2,6-dimethylaniline [19216-40-1], and N-(N-dimethylphenylalanyl)ephedrine (II) [10385-91-8] and their interaction with structural proteins of innervated membrane (frog heart) was given. Under various pH conditions (6.2-8.3), the anesthetics were ...


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Item type:Article
Additional Information (public):CAN 78:79558 1-3 Pharmacodynamics 2480-20-8; 2673-32-7; 5042-94-4; 7232-10-2; 7232-11-3; 7232-12-4; 7275-84-5; 7278-68-4; 19216-71-8; 19216-72-9; 19216-73-0; 19237-86-6 Role: PROC (Process) (membrane binding of, anesthetic activity in relation to)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
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Keywords:Molecular structure-biological activity relationship (anesthetic, of aminoacryldimethylaniline derivs.) Anesthetics (membrane binding of, aminoacryldimethylaniline derivs. in relation to) Membranes (protein, aminoacryldimethylaniline derivs. binding to) Isomerism and Isomers (stereo-, of dimethylphenylalanylephedrine, membrane binding in relation to) anesthetic interaction membrane protein ephedrine isomer anesthesia membrane
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:18177
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