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Mechanism of action of local anesthetics. 6. Binding of local anesthetics to complementary membrane structures

Schönenberger, Helmut ; Petter, A. ; Zwez, W.



Abstract

The function of various mol. groups in anesthetic agents such as N-(N-dimethylalanyl)-2,6-dimethylaniline (I) [19216-39-8], N-(N-dimethylphenylalanyl)-2,6-dimethylaniline [19216-40-1], and N-(N-dimethylphenylalanyl)ephedrine (II) [10385-91-8] and their interaction with structural proteins of innervated membrane (frog heart) was given. Under various pH conditions (6.2-8.3), the anesthetics were ...

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