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Cytostatics. 23. Tumor-inhibiting effect of N,N.',N"-tris(hydroxymethyl)melamine and analogous compounds

Schönenberger, Helmut ; Schmidt, F. ; Bindl, L.


The carcinostatic effects of 7 aminotriazine derivs. [I, R = R1 = NHCH2OH (II), N(CH2OMe)2, NHCH2SO3Na, N(CH2SEt)2, or morpholinomethylamino (III), or R = NHCH2CN, R1 = Cl or NH2] were tested on Yoshida sarcoma and sarcoma 180 in rats. Only N,N',N''-tris(hydroxymethyl)melamine (II) [1017-56-7] had a marked effect. III also inhibited tumor growth, but did not increase the survival time. II and III ...


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