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Synthesis of local anesthetics

Schönenberger, Helmut ; Vogel, H. ; Bamann, E.



Abstract

The prepns. are described of the local anesthetic compds. MeO2CCH2CHRNHCHRCH2CH2OBz and the N-methyl derivs. 3-Amino-1-butanol (I), b11 63-5 Deg, was prepd. in 37.8% yield by dropwise addn. of a suspension of 28.5 g. LiAlH4 in 900 ml. abs. Et2O to an abs. Et2O soln. (500 ml.) of 0.4 mole methyl acetoacetate oxime (II), and stirring the gently boiling mixt. for 5 hrs. Me beta ...

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