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Reactions of alpha -aminonitriles. IX. Reaction of alpha -aminonitriles with alkynyl and alkyl Grignard compounds

Thies, Heinrich, Schönenberger, Helmut and Beutel, R. (1972) Reactions of alpha -aminonitriles. IX. Reaction of alpha -aminonitriles with alkynyl and alkyl Grignard compounds. Archiv der Pharmazie 305 (1), pp. 18-26.

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Reaction of piperidino-acetonitriles (I, R = Ph, p-ClC6H4, m-HOC6H4, 3,4-(MeO)2-C6H3); with R1C==CMgBr and R1CH2CH2MgBr (R1 = Me, Bu) in inert solvents gave the corresponding II and III in 22.9-48.0 and 16-47.0% yields, resp. III had parasympatholytic activity.

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Item type:Article
Additional Information (public):CAN 76:126734 27 Heterocyclic Compounds (One Hetero Atom) 36018-60-7P; 36018-61-8P; 36018-62-9P; 36057-68-8P; 36057-69-9P; 36057-77-9P; 36057-78-0P; 36057-81-5P; 36057-82-6P; 36057-83-7P; 36057-84-8P; 36057-85-9P; 36057-86-0P; 36057-87-1P; 36474-99-4P; 37679-25-7P; 37679-53-1P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 3010-03-5D (1-Piperidineacetonitrile) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with alkynyl- and alkylmagnesium bromides)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
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Keywords:Grignard reagents Role: RCT (Reactant), RACT (Reactant or reagent) (alkynyl and alkyl, reaction with aminonitriles) piperidino alkyne alkane piperidino parasympatholytic
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:18203
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