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Reactions of alpha -amino nitriles. 10. Synthesis of 1-amino-1-aryl-2-alkynes with cholinergic and cholinolytic properties

Thies, Heinrich ; Schönenberger, Helmut ; El-Zanaty, M.


Thirty-two RR1NCHR2C==CR3 [R = R1 = Me, Et, NRR1 = 1-pyrrolidinyl, piperidino, morpholino, R2 = 3,4-(MeO)2C6H3, Ph, m-HOC6H4, p-ClC6H4, o-MeOC6H4, p-MeOC6H4, 3,4-HO(MeO)C6H3, 3,4-(methylenedioxy)phenyl, R3 = Pr, Bu, pentyl, Ph, H] and/or their picrates or hydrochlorides were prepd. (37-88%) by the reaction of RR1NCHR2CN and RC==CMgBr.

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