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CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors.

Corbo, Joseph C ; Lawrence, Karen A ; Karlstetter, Marcus ; Myers, Connie A ; Abdelaziz, Musa ; Dirkes, William ; Weigelt, Karin ; Seifert, Martin ; Benes, Vladimir ; Fritsche, Lars G ; Weber, Bernhard H. F. ; Langmann, Thomas



Abstract

Approximately 98% of mammalian DNA is noncoding, yet we understand relatively little about the function of this enigmatic portion of the genome. The cis-regulatory elements that control gene expression reside in noncoding regions and can be identified by mapping the binding sites of tissue-specific transcription factors. Cone-rod homeobox (CRX) is a key transcription factor in photoreceptor ...

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