Solution structure of the Ran-binding domain 2 of RanBP2 and its interaction with the C terminus of Ran

DOI to cite this document:: 10.5283/epub.1873

Geyer, J. Peter ; Döker, Rolf ; Kremer, Werner ; Zhao, Xiaodong ; Kuhlmann, Jürgen ; Kalbitzer, Hans-Robert

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Date of publication of this fulltext: 05 Aug 2009 13:34

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Abstract

The termination of export processes from the nucleus to the cytoplasm in higher eukaryotes is mediated by binding of the small GTPase Ran as part of the export complexes to the Ran-binding domains (RanBD) of Ran-binding protein 2 (RanBP2) of the nuclear pore complex. So far, the structures of the first RanBD of RanBP2 and of RanBP1 in complexes with Ran have been known from X-ray crystallographic ...