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Der Einfluss humanen Wildtyp-Alpha-Synucleins auf die Adulte Neurogenese am Beispiel der transgenen mThy1-Alpha-Synuclein-Maus

Schreglmann, Sebastian Robert (2011) Der Einfluss humanen Wildtyp-Alpha-Synucleins auf die Adulte Neurogenese am Beispiel der transgenen mThy1-Alpha-Synuclein-Maus. PhD, Universität Regensburg.

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Date of publication of this fulltext: 04 Jan 2011 11:28

Abstract (German)

Einleitung: Das pathologische Charakteristikum des Parkinson-Syndroms ist die Akkumulation und Aggregation von α-Synuclein in Neuronen des Gehirns. Transgene (tg) humanes Wildtyp (h-wt) α-Synuclein-Tiere simulieren bestimmte Aspekte des Parkinson-Syndroms. Die adulte Neurogenese, die Neubildung neuer Neurone im adulten hippocampalen Gyrus dentatus und im System Subventrikularzone – Bulbus ...


Translation of the abstract (English)

Introduction: The pathological hallmark of Parkinson’s disease (PD) is the accumulation and aggregation of α-synuclein in neurons throughout the brain. Human-wildtype (h-wt) α-synuclein transgenic (tg) animals mimic certain neuropathological aspects of PD. Adult neurogenesis, the generation of new neurons in the adult hippocampal dentate gyrus and the subventricular zone – olfactory bulb system, ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:4 January 2011
Referee:PD Dr. Beate Winner and Prof. Dr. Olaf Strauß
Date of exam:20 December 2010
Institutions:Medicine > Lehrstuhl für Neurologie
Interdisciplinary Subject Network:Not selected
Keywords:Adulte Neurogenese, Parkinson, α-Synuclein, mThy1, Hippocampus, Bulbus olfactorius, Dendriten, Synaptische Spines, retrovirales Tracing adult neurogenesis, parkinson, α-synuclein, mThy1, hippocampus, olfactory bulb, dendrites, synaptic spines, retroviral tracing
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:18849
Owner only: item control page


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