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Comparison of reduced and standard light application in photodynamic therapy of the eye in two rabbit models

DOI to cite this document:
10.5283/epub.1931
Framme, C. ; Flucke, B. ; Birngruber, R.
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Date of publication of this fulltext: 05 Aug 2009 13:34


Abstract

Current PDT treatment for age-related macular degeneration uses a standard radiant exposure of 50 J/cm(2) stop at an irradiance of 600 mW/cm(2) stop. However; there is a general problem with the unusually high irradiance; in fact, the rate of photochemical production of singlet oxygen may be limited by insufficiently oxygenized neovascular tissue. It was the aim of this study to evaluate the ...

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