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Regulation of adult neurogenesis in Huntington's disease:
The role of TGF-beta1 signaling in the neurogenic niche

Kandasamy, Mahesh (2011) Regulation of adult neurogenesis in Huntington's disease:
The role of TGF-beta1 signaling in the neurogenic niche.
PhD, Universität Regensburg.

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Date of publication of this fulltext: 07 Feb 2011 13:03

Abstract (English)

In the adult brain, new neurons are continuously produced in the subgranular zone (SGZ) of the hippocampus and in the subventricular zone (SVZ) of the lateral ventricles. This process includes neural stem and progenitor cell maintenance, proliferation, neuronal differentiation, integration and survival. These neural stem cell niches are composed and regulated by its cellular, extracellular matrix ...

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Translation of the abstract (German)

Im adulten Gehirn werden in der subgranularen Zone (SGZ) des Hippocampus und in der Subventrikularzone (SVZ) der Seitenventrikel kontinuierlich neue Nervenzellen produziert. Dieser Prozess umfasst die Erhaltung neuraler Stamm- und Progenitorzellen, ihre Proliferation, neuronale Differenzierung, Integration und das Überleben dieser Zellen. Diese neuralen Stammzellnischen bestehen aus und werden ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:7 February 2011
Referee:Prof. Dr. Inga Neumann
Date of exam:14 December 2010
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann)
Interdisciplinary Subject Network:Not selected
Keywords:Neurogenesis, Huntingtons Disease, TGF-beta1, Smad2
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:19349
Owner only: item control page

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