Regulation of mesenchymal stem cell and chondrocyte differentiation by MIA

DOI to cite this document:: 10.5283/epub.1938

Tscheudschilsuren, G. ; Bosserhoff, A. K.

; Schlegel, J. ; Vollmer, D. ; Anton, A. ; Alt, V. ; Schnettler, R. ; Brandt, J. ; Proetzel, G.

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Date of publication of this fulltext: 05 Aug 2009 13:34

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Abstract

Melanoma inhibitory activity (MIA), also referred to as cartilage-detived retinoic acid-sensitive protein (CD-RAP), an 11-kDa secreted protein, is mainly expressed in cartilaginous tissue during embryogenesis and adulthood. Currently, the function of MIA in cartilage tissue is not understood. Here, we describe that MIA acts as a chemotactic factor on the mesenchymal stem cell line C3HIOT1/2, ...