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A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells

DOI to cite this document:
10.5283/epub.1940
Blindt, Rüdiger ; Vogt, Felix ; Astafieva, Irina ; Fach, Christian ; Hristov, Mihail ; Krott, Nicole ; Seitz, Berthold ; Kapurniotu, Aphrodite ; Kwok, Connie ; Dewor, Manfred ; Bosserhoff, Anja-Katrin ; Bernhagen, Jürgen ; Hanrath, Peter ; Hoffmann, Rainer ; Weber, Christian
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Date of publication of this fulltext: 05 Aug 2009 13:35


Abstract

OBJECTIVES: Novel stents loaded with an integrin-binding cyclic Arg-Gly-Asp peptide (cRGD) were analyzed for their potential to limit coronary neointima formation and to accelerate endothelialization by attracting endothelial progenitor cells (EPCs). BACKGROUND: Re-endothelialization is important for healing after arterial injury. METHODS: Effects of cRGD on EPC number, recruitment in flow, and ...

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