Regulation of integrin activity by MIA

DOI to cite this document:: 10.5283/epub.1941

Bauer, Richard ; Humphries, Martin ; Fässler, Reinhard ; Winklmeier, Andreas ; Craig, Sue E ; Bosserhoff, Anja-Katrin

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Date of publication of this fulltext: 05 Aug 2009 13:35

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Abstract

MIA (melanoma inhibitory activity) has been identified as a small protein secreted from malignant melanoma cells, which interacts with extracellular matrix proteins including fibronectin. Here, we show that MIA negatively regulates the activity of the mitogen-activated protein kinase pathway in malignant melanoma. Using far Western blotting and co-immunoprecipitation we searched for MIA-binding ...