MIB-1 and MCM-2 immunohistochemical analysis does not aid in identification of serrated colorectal polyps with abnormal proliferation

DOI to cite this document:: 10.5283/epub.1943

Gray, David ; Obermann, Ellen C. ; Evans, Mark ; Hartmann, Arndt ; Cooper, Kumarasen ; Blaszyk, Hagen

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Date of publication of this fulltext: 05 Aug 2009 13:35

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Abstract

We investigated the staining characteristics of serrated polyps with abnormal proliferation (SPAP) using MIB-1 and MCM-2 to determine if they could provide assistance in delineating SPAPs from traditional hyperplastic polyps (HPs). Using published morphologic criteria we reviewed H&E slides of 107 polyps from 80 patients. Thirty-nine (36.4%) polyps met the criteria for SPAP Within a given region, ...