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Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer

DOI to cite this document:
10.5283/epub.1944
Dahl, Edgar ; Kristiansen, Glen ; Gottlob, Kathrin ; Klaman, Irina ; Ebner, Elke ; Hinzmann, Bernd ; Hermann, Klaus ; Pilarsky, Christian ; Dürst, Matthias ; Klinkhammer-Schalke, Monika ; Blaszyk, Hagen ; Knuechel, Ruth ; Hartmann, Arndt ; Rosenthal, André ; Wild, Peter J.
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Date of publication of this fulltext: 05 Aug 2009 13:35


Abstract

PURPOSE: The aim of the present study was to identify human genes that might prove useful in the diagnosis and therapy of primary breast cancer. EXPERIMENTAL DESIGN: Twenty-four matched pairs of invasive ductal breast cancer and corresponding benign breast tissue were investigated by a combination of laser microdissection and gene expression profiling. Differential expression of candidate genes ...

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