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Diffuse large B-cell lymphoma with overexpression of cyclin e substantiates poor standard treatment response and inferior outcome

Tzankov, Alexandar, Gschwendtner, Andreas, Augustin, Florian, Fiegl, Michael, Obermann, Ellen C., Dirnhofer, Stephan and Went, Philip (2006) Diffuse large B-cell lymphoma with overexpression of cyclin e substantiates poor standard treatment response and inferior outcome. Clinical cancer research : an official journal of the American Association for Cancer Research 12 (7 Pt 1), pp. 2125-2132.

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Date of publication of this fulltext: 05 Aug 2009 13:35

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Other URL: http://dx.doi.org/10.1158/1078-0432.CCR-05-2135


Abstract

PURPOSE: Gold standard to predict survival and stratify patients for risk-adapted therapy in diffuse large B-cell lymphoma (DLBCL) is the international prognostic index, although it does not consider the molecular heterogeneity of DLBCL. Deregulation of cyclin E (CCNE) is a strong predictor of poor prognosis in some neoplastic diseases. In tumor cells, it induces chromosomal instability with an ...

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Item type:Article
Date:1 April 2006
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10.1158/1078-0432.CCR-05-2135DOI
16609025PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:1946
Owner only: item control page

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