Diffuse large B-cell lymphoma with overexpression of cyclin e substantiates poor standard treatment response and inferior outcome

DOI to cite this document:: 10.5283/epub.1946

Tzankov, Alexandar

; Gschwendtner, Andreas ; Augustin, Florian ; Fiegl, Michael ; Obermann, Ellen C. ; Dirnhofer, Stephan ; Went, Philip

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Date of publication of this fulltext: 05 Aug 2009 13:35

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Abstract

Purpose: Gold standard to predict survival and stratify patients for risk-adapted therapy in diffuse large B-cell lymphoma (DLBCL) is the international prognostic index, although it does not consider the molecular heterogeneity of DLBCL. Deregulation of cyclin E (CCNE) is a strong predictor of poor prognosis in some neoplastic diseases. In tumor cells, it induces chromosomal instability with an ...