Repression of cytochrome P450 activity in human hepatocytes in vitro by a novel hepatotrophic factor, augmenter of liver regeneration

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1959

Thasler, Wolfgang E. ; Dayoub, Rania ; Mühlbauer, Marcus ; Hellerbrand, Claus ; Singer, Thomas ; Gräbe, Anja ; Jauch, Karl-Walter ; Schlitt, Hans-Jürgen ; Weiss, Thomas S.

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:35

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Pathological disorders of the liver were shown to be associated with an impairment of hepatic drug metabolism mediated in part by growth factors. Augmenter of liver regeneration (ALR) is a novel liver-specific hepatotrophic growth factor, whereas its action on cytochrome P450 (P450) metabolism is completely unknown. Application of ALR to primary human hepatocytes in vitro reduced P450 isoenzyme ...