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Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles.

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Plander, M. ; Seegers, Silvia ; Ugocsai, P. ; Diermeier-Daucher, S. ; Iványi, J. ; Schmitz, G. ; Hofstädter, F. ; Schwarz, S. ; Orso, E. ; Knüchel, R. ; Brockhoff, G.
Date of publication of this fulltext: 14 Feb 2011 12:43


Chronic lymphocytic leukemia (CLL) is a malignancy of mature B-lymphocytes that manifests in a variety of clinical courses. The accumulation of CLL-cells is primarily caused by defective apoptosis; however, a higher proliferative capacity has also been found to correlate with poorer prognostic factors. Proliferating CLL-cells are confined to specialized structures called pseudofollicles, which ...


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