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Efficient Synthesis of 3,4-Dihydropyrimidin-2-ones in Low Melting Tartaric Acid – Urea Mixtures

URN to cite this document:
urn:nbn:de:bvb:355-epub-196269
DOI to cite this document:
10.5283/epub.19626
Gore, S. ; Baskaran, S. ; König, Burkhard
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Date of publication of this fulltext: 16 Feb 2011 09:05


Abstract

A general, efficient and green method for the synthesis of dihydropyrimidinones is described under mild conditions employing low melting mixtures of L-(+)-tartaric acid and urea derivatives as a novel reaction medium. The melt plays a triple role: as solvent, as catalyst and as reactant,
furnishing highly functionalized dihydropyrimidinones in good to excellent yields.


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