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Efficient Synthesis of 3,4-Dihydropyrimidin-2-ones in Low Melting Tartaric Acid – Urea Mixtures

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Gore, S. ; Baskaran, S. ; König, Burkhard
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 16 Feb 2011 09:05


A general, efficient and green method for the synthesis of dihydropyrimidinones is described under mild conditions employing low melting mixtures of L-(+)-tartaric acid and urea derivatives as a novel reaction medium. The melt plays a triple role: as solvent, as catalyst and as reactant,
furnishing highly functionalized dihydropyrimidinones in good to excellent yields.

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