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Skin explant model of human graft-versus-host disease: prediction of clinical outcome and correlation with biological risk factors

Wang, Xiao-Nong ; Collin, Matthew ; Sviland, Lisbet ; Marshall, Scott ; Jackson, Graham ; Schulz, Ute ; Holler, Ernst ; Karrer, Sigrid ; Greinix, Hildegard ; Elahi, Fariborz ; Hromadnikova, Ilona ; Dickinson, A. M.



Abstract

A human skin explant model has been used to predict the clinical outcome and to study the immunopathology of human graft-versus-host disease (GVHD). Whether the model gives the same predictive effect for GVHD in different hematopoietic stem cell transplantation (HSCT) settings has not been assessed. It is also unknown whether the skin explant result reflects the known biological risk factors for ...

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