Colloidal silica nanoparticles for use in click chemistry-based conjugations and fluorescent affinity assays

DOI to cite this document:: 10.5283/epub.19963

Achatz, E. ; Heiligtag, Florian J. ; Li, Xiaohua ; Link, Martin ; Wolfbeis, Otto S.

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Date of publication of this fulltext: 18 Mar 2011 06:47

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Abstract

Silica nanoparticles (SiNPs) with an average diameter of 25 nm were prepared by a one-pot method that involves the formation of a silica core that is subsequently covered with a shell functionalized with either azido groups or alkyne groups for use in copper(I)-catalyzed click reactions. Respective triethoxysilane reagents are presented The SiNPs were (a) rendered fluorescent by click conjugation ...