Highly resolved dose–response functions for drug-modulated bacteria cultivation obtained by fluorometric and photometric flow-through sensing in microsegmented flow

DOI to cite this document:: 10.5283/epub.20006

Funfak, Anette ; Hartung, Regina ; Cao, Jialan ; Martin, Karin ; Wiesmüller, Karl-Heinz ; Wolfbeis, Otto S.

; Köhler, J. Michael

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Date of publication of this fulltext: 18 Mar 2011 06:58

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Abstract

The application of the micro fluid segment technique for the investigation of highly resolved dose-response relationship at the physiological parameters segment-internal pH and growth of the cell culture is introduced. The method was used to study the concentration-dependent response of an Escherichia coli culture for the effectors 2,4-dinitrophenol (DNP) and an antibacterial peptide amide ...