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Highly resolved dose–response functions for drug-modulated bacteria cultivation obtained by fluorometric and photometric flow-through sensing in microsegmented flow

Funfak, Anette ; Hartung, Regina ; Cao, Jialan ; Martin, Karin ; Wiesmüller, Karl-Heinz ; Wolfbeis, Otto S. ; Köhler, J. Michael
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Date of publication of this fulltext: 18 Mar 2011 06:58


Abstract

The application of the micro fluid segment technique for the investigation of highly resolved dose–response relationship at the physiological parameters segment–internal pH and growth of the cell culture is introduced. The method was used to study the concentration-dependent response of an Escherichia coli culture for the effectors 2,4-dinitrophenol (DNP) and an antibacterial peptide amide ...

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