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The Tunable Functionality of alpha,beta-Unsaturated Carbonyl Compounds Enables Their Differential Application in Biological Systems

Amslinger, Sabine



Abstract

alpha,beta-Unsaturated carbonyl compounds as potential drug candidates is a controversial topic since their potential Michael acceptor activity can lead to cell damage and cytotoxicity. Nevertheless, the alpha,beta-unsaturated carbonyl functionality can be employed as a tool to fine tune biological activity by directly manipulating this entity. Depending on their electronic properties, ...

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