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Synthesis of (-)-Geissman Waiss Lactone, cis gamma-butyrolactone derivatives and gamma-peptides

Mohd Ali, Mohd Tajudin (2012) Synthesis of (-)-Geissman Waiss Lactone, cis gamma-butyrolactone derivatives and gamma-peptides. PhD, Universität Regensburg.

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Date of publication of this fulltext: 13 Apr 2012 09:34

Abstract (English)

A new asymmetric approach towards a cis gamma-lactone amino acid-containing tetrapeptide and antitubercular cis, gamma-butyrolactones and gamma-substituted butenolides from cis- azidolactone acid is hereby described. In addition, a facile formal synthesis of (-)-Geissman-Waiss lactone from trans-azido trimethylsiloxycyclohexene is also reported.

Translation of the abstract (German)

Eine neue asymmetrische Methode zur Darstellung eines Aminosäure enthaltenden cis-gamma-Lakton-Tetrapeptids, antituberkulösen cis, gamma-Butyrolaktonen und gamma-substituierten Butenoliden ausgehend von cis-Azidolactoncarbonsäure wird hier beschrieben. Zusätzlich wird eine einfache formale Synthese von (-)-Geissman-Waiss-Lakton aus enantiomerenreinem trans-Azido-Trimethylsiloxycyclohexen aufgezeigt.

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Item type:Thesis of the University of Regensburg (PhD)
Date:13 April 2012
Referee:Prof. Dr. Oliver Reiser
Date of exam:29 March 2011
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Interdisciplinary Subject Network:Not selected
Keywords:azidosiloxycyclohexene, gamma-amino acid, tetrapeptide, antimycobacterial butyrolactones, Geissman-Waiss lactone
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:20310
Owner only: item control page


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