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Synthesis of (-)-Geissman Waiss Lactone, cis gamma-butyrolactone derivatives and gamma-peptides
Mohd Ali, Mohd Tajudin (2012) Synthesis of (-)-Geissman Waiss Lactone, cis gamma-butyrolactone derivatives and gamma-peptides. PhD, Universität Regensburg.Date of publication of this fulltext: 13 Apr 2012 09:34
Thesis of the University of Regensburg
DOI to cite this document: 10.5283/epub.20310
Abstract (English)
A new asymmetric approach towards a cis gamma-lactone amino acid-containing tetrapeptide and antitubercular cis, gamma-butyrolactones and gamma-substituted butenolides from cis- azidolactone acid is hereby described. In addition, a facile formal synthesis of (-)-Geissman-Waiss lactone from trans-azido trimethylsiloxycyclohexene is also reported.
Translation of the abstract (German)
Eine neue asymmetrische Methode zur Darstellung eines Aminosäure enthaltenden cis-gamma-Lakton-Tetrapeptids, antituberkulösen cis, gamma-Butyrolaktonen und gamma-substituierten Butenoliden ausgehend von cis-Azidolactoncarbonsäure wird hier beschrieben. Zusätzlich wird eine einfache formale Synthese von (-)-Geissman-Waiss-Lakton aus enantiomerenreinem trans-Azido-Trimethylsiloxycyclohexen aufgezeigt.
Involved Institutions
Details
| Item type | Thesis of the University of Regensburg (PhD) |
| Date | 13 April 2012 |
| Referee | Prof. Dr. Oliver Reiser |
| Date of exam | 29 March 2011 |
| Institutions | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Interdisciplinary Subject Network | Not selected |
| Keywords | azidosiloxycyclohexene, gamma-amino acid, tetrapeptide, antimycobacterial butyrolactones, Geissman-Waiss lactone |
| Dewey Decimal Classification | 500 Science > 540 Chemistry & allied sciences |
| Status | Published |
| Refereed | Yes, this version has been refereed |
| Created at the University of Regensburg | Yes |
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-203100 |
| Item ID | 20310 |
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