In Vivo Phosphorescence Imaging of pO2 Using Planar Oxygen Sensors

DOI to cite this document:: 10.5283/epub.20355

Babilas, Philipp ; Liebsch, Gregor ; Schacht, Vivien ; Klimant, Ingo ; Wolfbeis, Otto S.

; Szeimies, Rolf-Markus ; Abels, Christoph

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Date of publication of this fulltext: 04 Apr 2011 10:37

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Abstract

Objective: Oxygen-dependent quenching of luminescence of metal porphyrin complexes has been used to image the pO(2) distribution over tumor and normal tissue. Methods: An experimental setup is described using a platinum(II)-octaethyl-porphyrin immobilized in a polystyrene matrix as transparent planar sensor. Results: Sensitivity over a broad range is high at low pO(2) values (+/-0.2 mm Hg at 0 mm ...