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In Vivo Phosphorescence Imaging of pO2 Using Planar Oxygen Sensors

Babilas, Philipp ; Liebsch, Gregor ; Schacht, Vivien ; Klimant, Ingo ; Wolfbeis, Otto S. ; Szeimies, Rolf-Markus ; Abels, Christoph
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Date of publication of this fulltext: 04 Apr 2011 10:37


Abstract

Objective: Oxygen-dependent quenching of luminescence of metal porphyrin complexes has been used to image the pO2 distribution over tumor and normal tissue. Methods: An experimental setup is described using a platinum(II)–octaethyl–porphyrin immobilized in a polystyrene matrix as transparent planar sensor. Results: Sensitivity over a broad range is high at low pO2 values (± 0.2 mm Hg at 0 mm Hg; ...

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