Inhibition of infectious human immunodeficiency virus type 1 particle formation by Gag protein-derived peptides

URN to cite this document:: urn:nbn:de:bvb:355-epub-203938
DOI to cite this document:: 10.5283/epub.20393

Niedrig, M. ; Gelderblom, H. R. ; Pauli, G. ; März, J. ; Bickhard, H. ; Wolf, Hans J. ; Modrow, Susanne

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Date of publication of this fulltext: 06 Apr 2011 07:55

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Abstract

Sequential overlapping Gag protein-derived oligopeptides of human immunodeficiency virus type 1 (HIV-1) 22 to 24 amino acids long, were synthesized and tested in vitro for antiviral activity. Two synthetic peptides, one derived from the matrix protein p17 (NPGLLETSEGCRQ, amino acids 47 to 59) and one located in the capsid protein p24 (PAATLEEMMTA, amino acids 339 to 349) inhibited the production ...