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Assembly and extracellular release of chimeric HIV-1 Pr55gag retrovirus-like particles

URN to cite this document:
urn:nbn:de:bvb:355-epub-203940
Wagner, R. ; Deml, Ludwig ; Fliessbach, H. ; Wanner, G. ; Wolf, Hans J.
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Date of publication of this fulltext: 05 Apr 2011 07:07


Abstract

The HIV-1 Pr55gag precursors were previously shown to assemble and bud from a variety of different cell types as noninfectious virus-like particles (VLPs) resembling immature HIV virions. The use of these VLPs as an immunogenic and autologous carrier component may allow the presentation of defined epitopes deduced from reading frames other than gag to the immune system, thereby avoiding the ...

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