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Identification of a region in the Pr55gag-polyprotein essential for HIV-1 particle formation

URN to cite this document:
von Poblotzki, A. ; Wagner, Ralf ; Niedrig, M. ; Wanner, G. ; Wolf, Hans J. ; Modrow, Susanne
Date of publication of this fulltext: 07 Apr 2011 06:43


The pr55gag polyprotein of HIV-1 plays a critical role in the formation of immature virus particles in the cell and during the budding process. We investigated the influence of amino acid substitutions in the p24CA- region of the gag polyprotein on the viral assembly process. Deletion of the amino acids 341-352 in the carboxy terminal part of the p24CA resulted in a loss of the capacity of the ...


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