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The lytic transition of Epstein-Barr virus is imitated by recombinant B-cells

URN to cite this document:
urn:nbn:de:bvb:355-epub-204114
Marschall, M. ; Alliger, P. ; Schwarzmann, F. ; Bogedain, C. ; Brand, M. ; Reichelt, B. ; Glaser, G. ; Wolf, Hans J.
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Date of publication of this fulltext: 12 Apr 2011 06:29


Abstract

Lytic transition of Epstein-Barr virus (EBV) is initiated by distinct immediate early regulators of the viral cycle, in synchronization to temporary, permissive conditions during host cell differentiation. We developed eukaryotic vectors suitable to imitate the processes involved in lytic transition in cell culture systems. Two stable B cell lines were established: R59Z activator cells were used ...

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