Detection of Epstein-Barr virus DNA in nasopharyngeal carcinoma using a non-radioactive digoxigenin-labelled probe

URN to cite this document:: urn:nbn:de:bvb:355-epub-204878
DOI to cite this document:: 10.5283/epub.20487

Permeen, A. M. ; Sam, C. K. ; Pathmanathan, R. ; Prasad, U. ; Wolf, Hans J.

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Date of publication of this fulltext: 13 Apr 2011 08:28

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Abstract

The presence of Epstein Barr virus (EBV) DNA in biopsies from the post-nasal space (PNS) of patients suspected of nasopharyngeal carcinoma (NPC) was detected by in situ cytohybridization with an EBV DNA probe labelled with the novel labelling compound digoxigenin. The digoxigenin probe was hybridised to cryostat sections of NPC biopsies and subsequently detected by an enzyme immunoassay ...