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Use of synthetic oligopeptides in identification and characterization of immunological functions in the amino acid sequence of the envelope protein of HIV-1

Modrow, Susanne, Höflacher, B., Mellert, W., Erfle, V., Wahren, B. and Wolf, Hans J. (1989) Use of synthetic oligopeptides in identification and characterization of immunological functions in the amino acid sequence of the envelope protein of HIV-1. Journal of acquired immune deficiency syndromes 2 (1), pp. 21-27.

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Abstract

Following computer-assisted analysis of the amino acid sequence of various HIV-1 isolates, we synthesized a series of oligopeptides derived from variable and conserved regions of the envelope protein complex gp120/gp41. The peptides were used in ELISA tests for their reactivity with human antisera from HIV-1 positive individuals; patients with clinically manifested AIDS showed only a rather ...

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Item type:Article
Date:1989
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
2537398PubMed ID
Classification:
NotationType
Acquired Immunodeficiency Syndrome/immunologyMESH
Amino Acid SequenceMESH
AnimalsMESH
Enzyme-Linked Immunosorbent AssayMESH
HIV Antigens/immunologyMESH
HIV Envelope Protein gp120MESH
HIV Envelope Protein gp41MESH
HIV-1/immunologyMESH
HumansMESH
Lymphocyte ActivationMESH
Oligopeptides/diagnostic useMESH
RabbitsMESH
Retroviridae Proteins/immunologyMESH
Viral Envelope Proteins/immunologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Item ID:20521
Owner only: item control page

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