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Use of synthetic oligopeptides in identification and characterization of immunological functions in the amino acid sequence of the envelope protein of HIV-1

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Modrow, Susanne ; Höflacher, B. ; Mellert, W. ; Erfle, V. ; Wahren, B. ; Wolf, Hans J.
Date of publication of this fulltext: 18 Apr 2011 11:32


Following computer-assisted analysis of the amino acid sequence of various HIV-1 isolates, we synthesized a series of oligopeptides derived from variable and conserved regions of the envelope protein complex gp120/gp41. The peptides were used in ELISA tests for their reactivity with human antisera from HIV-1 positive individuals; patients with clinically manifested AIDS showed only a rather ...


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