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Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS

URN to cite this document:
urn:nbn:de:bvb:355-epub-205533
Starcich, B. R. ; Hahn, B. H. ; Shaw, G.M. ; McNeely, P. D. ; Modrow, Susanne ; Wolf, Hans J. ; Parks, E. S. ; Parks, W. P. ; Josephs, S. F. ; Gallo, R. C.
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Date of publication of this fulltext: 20 Apr 2011 12:42


Abstract

To determine the extent and nature of genetic variation present in independent isolates of HTLV-III/LAV, the nucleotide sequences of the entire envelope gene and parts of gag and pol were determined for two AIDS viruses. The results indicated that variation throughout the viral genome is extensive and that the envelope gene in particular is most highly variable. Within the envelope, changes were ...

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