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Regulation of CFTR and its contribution to other epithelial Cl- channels

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Kongsuphol, Patthara
Date of publication of this fulltext: 04 May 2011 08:15

Abstract (English)

Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is a cAMP dependent Cl- channel that is expressed mainly on the apical membrane of epithelial cells. CFTR plays an essential role in electrolyte and water homeostasis. Defects in CFTR cause CF disease, which is the most common lethal genetic disorder among Caucasians. Besides functioning as a Cl- channel, CFTR also acts as a regulator of ...


Translation of the abstract (German)

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) ist ein cAMP-abhängiger Cl--Kanal, der in der apikalen Membran von Epithelzellen exprimiert wird. CFTR spielt eine essentielle Rolle in der Elektrolyt- und Wasser-Homöostase. Mutationen im CFTR-Protein verursachen die Erkrankung Mukoviszidose (Cystische Fibrose), eine tödlich Erbkrankheit, die vor allem bei Kaukasiern auftritt. CFTR ...


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