Lymphoproliferative disease in a cotton-top marmoset after inoculation with infectious mononucleosis-derived Epstein-Barr virus

URN to cite this document:: urn:nbn:de:bvb:355-epub-207582
DOI to cite this document:: 10.5283/epub.20758

Werner, J. ; Wolf, Hans J. ; Apodaca, J. ; zur Hausen, H.

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Date of publication of this fulltext: 04 May 2011 06:38

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Abstract

Injection of concentrated EBV derived from cells of the Kaplan line of infectious mononucleosis (IM) origin resulted in malignant lymphoproliferation in one out of three cotton-top marmosets 6 weeks after inoculation. Two additional animals receiving the same isolate after incubation with an antibody-containing human serum did not develop tumors. Inoculation of concentrated virus derived from the ...