Effects of light fractionation and different fluence rates on photodynamic therapy with 5-aminolaevulinic acid in vivo

DOI to cite this document:: 10.5283/epub.20766

Babilas, P. ; Schacht, V. ; Liebsch, G. ; Wolfbeis, Otto S.

; Landthaler, M. ; Szeimies, R.-M. ; Abels, C.

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Date of publication of this fulltext: 13 May 2011 08:20

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Abstract

To improve efficacy of photodynamic therapy (PDT) with intravenously administered 5-aminolaevulinic acid (ALA) fractionating the light dose or reducing the light intensity may be a possibility. Therefore, Syrian Golden hamster's were fitted with dorsal skinfold chambers containing an amelanotic melanoma (n = 26). PDT was performed (100mWcm(-2), 100Jcm(-2), continuously or fractionated, and 25 mW ...